SnapShot: Dendritic Cells

SnapShot: Dendritic Cells

Dendritic Cells in Transplant Tolerance

Dendritic cells (DCs) are a heterogeneous family of professional APCs involved in priming adaptive immune responses. Donor DCs (direct pathway of allorecognition) and recipient DCs presenting processed donor major histocompatibility complex (MHC) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient T cell responses following organ tr...

SnapShot: Circulating Tumor Cells

Circulating tumor cells in the blood of patients are both signal flares for the existence of a tumor and harbingers of metastasis. With recent technological developments, these cells can be isolated and analyzed to provide insights into the biology of cancer spread and response to therapy and to offer new avenues for blood biomarker development.

SnapShot: Resident Memory T Cells

Resident memory T cells (TRM) comprise a subset of nonrecirculating memory T cells that remain positioned at common portals of reinfection. These include barrier tissues such as the mucosae and skin. TRM orchestrate the initial response to pathogens re-encountered at these locales, thereby accelerating protective immune responses.

SnapShot: Hair Follicle Stem Cells